R&D Scientist - Reagent Chemisty in Molecular Diagnostic Application

Company: Hologic, Inc.
Location: San Diego
Posted on: May 20, 2025

Job Description:

Discover a career with real meaning. One that offers the opportunity to showcase your talents, achieve measurable success and gain immense satisfaction by enabling healthier lives everywhere, every day.The San Diego Campus is the center of our Diagnostics Solutions Division. With the focus on Molecular Diagnostics, most products produced are utilized onboard innovative and fully automated sample-to-result instrument systems. The consumables required for patient testing are integral to our business. The business growth projections and new product development projects provide unique opportunities to enable our Purpose, Passion, and Promise to empower global health advancements.We are seeking an R&D Scientist specializing in reagent chemistry and molecular diagnostics, and in this role, you will lead and contribute to innovative research projects focusing on the interactions and behaviors of nucleic acids, proteins, buffers, and solvents. You will be responsible for developing and optimizing surface chemistry techniques, nucleic acid extraction from complex biological samples, and understanding lyophilization chemistry. Your expertise will drive advancements in nucleic acid amplification and sequence analysis, supporting our molecular diagnostics initiatives.This is a fully onsite position in San Diego, CA.Key Responsibilities:

• Research and Development:

• Design, plan, and execute complex experiments focusing on reagent chemistry, including the interactions of nucleic acids, proteins, buffers, and solvents.
• Design and develop new reagent formulations for use in molecular diagnostic assays.
• Optimize existing reagents to improve performance, stability, and manufacturability.
• Conduct feasibility studies and proof-of-concept experiments.
• Develop and optimize methodologies for nucleic acid extraction from complex biological samples.
• Conduct thorough analyses of biophysical and biochemical interactions, including surface chemistry interactions.
• Investigate and apply lyophilization techniques to stabilize biological samples and reagents.
• Molecular Diagnostics:
  • Develop and optimize reagents, including master mix etc, used in nucleic acid amplification and detection methods (e.g., PCR, RT-PCR, isothermal amplification, Methylation profiling).
  • Evaluate and implement new Chemistries and reagent formats to enhance molecular diagnostic capabilities.
  • Ensure the performance and reliability of diagnostic assays through maturing technologies for use in product development programs.
  • Collaborate with assay development teams to integrate reagents into diagnostic tests.
  • Identification and development of analytical techniques and methods to facilitate the transfer of reagents to Assay development and operations teams.
  • Project Leadership:
    • Lead and manage reagent development projects from conception through feasibility.
    • Coordinate with other scientists, engineers, and stakeholders to align on project objectives and deliverables.
    • Manage project milestones, deliverables and timelines.
    • Coordinate with cross-functional teams to ensure timely project completion.
    • Collaboration and Communication:
      • Collaborate with internal and external partners to advance scientific goals and share expertise.
      • Present research findings and progress to stakeholders, including senior management and scientific communities.
      • Prepare and publish scientific manuscripts, reports, and presentations.
      • Maintain detailed and accurate laboratory records.
      • Mentorship and Development:
        • Mentor and supervise junior scientists, providing guidance and support for their professional development.
        • Foster a collaborative and innovative research environment.
        • Stay current with scientific and technological advancements in the field of molecular diagnostics.Qualifications
          • Ph.D. in Chemistry, Biochemistry, Molecular Biology, or a related scientific discipline.
          • Extensive experience in reagent chemistry, including biophysical and biochemical interactions of nucleic acids, proteins, buffers, and solvents.
          • Strong expertise in surface chemistry interactions and nucleic acid extraction from complex biological samples.
          • Understanding of lyophilization chemistry and its applications in stabilizing biological samples.
          • Background in molecular diagnostics, including nucleic acid amplification and sequence analysis techniques.
          • Proven track record of scientific contributions, including publications and presentations.
          • Excellent problem-solving and critical-thinking skills.
          • Ability to lead and manage complex projects with multiple stakeholders.
          • Strong communication skills, both written and verbal.
          • Ability to work collaboratively in a team-oriented environment.Preferred Qualifications:
            • Experience with advanced analytical techniques and instrumentation relevant to reagent chemistry and molecular diagnostics.
            • Previous experience in a leadership or supervisory role within a research setting.
            • Understanding of regulatory requirements and quality control in molecular diagnostics.Work Environment:
              • Laboratory-based research with potential for occasional travel to conferences, meetings, or partner sites.
              • Collaborative and dynamic team setting.The annualized base salary range for this role is $95,800 to $149,900 and is bonus eligible. Final compensation packages will ultimately depend on factors including relevant experience, skillset, knowledge, geography, education, business needs, and market demand.Why Hologic?We are committed to making Hologic the company where top talent comes to grow. For you to succeed, we want to enable you with the tools and knowledge required and so we provide comprehensive training when you join as well as continued development and training throughout your career.If you have the right skills and experience, apply today!#LI-RF1 #Mid-level
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Keywords: Hologic, Inc., Lake Forest , R&D Scientist - Reagent Chemisty in Molecular Diagnostic Application, Other , San Diego, California