Senior Scientist

Company: Amgen
Location: Thousand Oaks
Posted on: January 2, 2026

Job Description:

Join Amgens Mission of Serving Patients At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do. Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. What you will do Inflammation Research - In Vivo Pharmacology Scientist . The Department of Inflammation Research is seeking a dedicated, driven and independent Principal Scientist (manager) to join the In Vivo Pharmacology (IVP) group as part of a fast-paced, integrated and interactive research group exploring therapeutics for Inflammation, Autoimmune, and Rare Disease programs. The successful candidate will be responsible for designing and executing experiments exploring and understanding the pharmacology of drug targets; generating, communicating pharmacology and preclinical data to support the progression of research projects, and providing technical expertise to therapeutic area scientists. This role has the potential for managing up to one report initially, contribution to project teams, collaboration with therapeutic area scientists and teams at multiple Amgen sites. Accountabilities: A driven, pro-active, independent, and enthusiastic scientist who wants to contribute to cutting edge science and serve patients in a highly productive team environment. Strong understanding of Immunology and Inflammation biology and principles. Willingness and curiosity to learn and explore new areas of research. Significant hands-on expertise in animal (mouse and rat) handling and in vivo techniques (i.v., i.p., p.o., i.d., s.c., i.t., bleeds, necropsy) preferred. Significant experience designing and executing concurrent in vivo preclinical inflammation and autoimmune disease models. Experience with colitis (DSS, CD45RBhi T cell transfer, IL-10 KO), lupus (NZB/W, MRL-lpr, Imiquimod), and arthritis (CIA, CAIA), GvHD models preferred. Experience in HS, PBC a plus. Hands-on experience in cellular, biochemical, histological, and molecular biology assay techniques (i.e. ELISA, MSD, quantitative RT-PCR, BCA protein measurements) preferred. Hands-on experience with multicolor flow cytometry including Spectral flow approaches and Immune cell populations is essential. Computer literacy, especially proficiency with GraphPad Prism, Excel, PowerPoint and Word. Attention to detail, excellent organizational and communication skills, accurate & timely record keeping and data analysis are essential. Demonstrated track record of independent critical thinking and scientific achievement. Demonstrated experience in pharmacology and in vivo models of inflammation/Immunology. Ability to work in a flexible team-oriented environment. Basic Qualifications: Doctorate degree OR Masters degree and 2 years of drug discovery experience OR Bachelors degree and 4 years of drug discovery experience Preferred Qualifications: PhD degree and post-doctoral training (or drug discovery experience) in the fields of Immunology, inflammation autoimmune disease, or related disciplines. 3-5 years of management experience in industry or academia. Experience working on project teams leading in vivo contributions. Thrive What you can expect of us As we work to develop treatments that take care of others, we also work to care for our teammates professional and personal growth and well-being. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors, including but not limited to, relevant skills, experience, and qualifications. Amgen offers a Total Rewards Plan comprising health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities including: Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. A discretionary annual bonus program. Stock-based long-term incentives. Award-winning time-off plans and bi-annual company-wide shutdowns. Flexible work models, including remote work arrangements, where possible. Apply now for a career that defies imagination Objects in your future are closer than they appear. Join us. careers.amgen.com In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information. Application deadline Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Keywords: Amgen, Lake Forest , Senior Scientist, Science, Research & Development , Thousand Oaks, California